BIO Integration (Dec 2022)

Utilizing Bacteria-Derived Components for Cancer Immunotherapy

  • Chengxiao Zhang,
  • Yulin Mu,
  • Ye Zhuo,
  • Taihua Li,
  • Feng-Jie Jin,
  • Chun-Zhin Jin,
  • Hyung-Gwan Lee,
  • Long Jin

DOI
https://doi.org/10.15212/bioi-2022-0022
Journal volume & issue
Vol. 3, no. 4
pp. 180 – 187

Abstract

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Bacteria-related cancer immunotherapy, because of its mechanisms and useful applications in the induction of anti-tumor immunity, has gained substantial attention in recent decades. Bacteria can enable targeting of tumors, and specifically can colonize the core tumor area. Because they contain many pathogen-associated molecular patterns—which efficiently stimulate immune cells, even within microenvironments that suppress anti-tumor immunity—bacteria boost immunological recognition leading to the destruction of malignant cells. This Editorial highlights various bacteria with immunotherapeutic effects and their by-products used as immunotherapeutics.

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