Dental pulp stem cells – A basic research and future application in regenerative medicine

Katarzyna Stefańska; Ana Angelova Volponi; Magdalena Kulus; Jadwiga Waśko; Maryam Farzaneh; Joanna Grzelak; Shirin Azizidoost; Paul Mozdziak; Dorota Bukowska; Paweł Antosik; Maciej Zabel; Marzenna Podhorska-Okołów; Piotr Dzięgiel; Marta Szcześniak; Maria Woszczyk; Bartosz Kempisty

Biomedicine & Pharmacotherapy (Sep 2024)

Dental pulp stem cells – A basic research and future application in regenerative medicine

Katarzyna Stefańska,
Ana Angelova Volponi,
Magdalena Kulus,
Jadwiga Waśko,
Maryam Farzaneh,
Joanna Grzelak,
Shirin Azizidoost,
Paul Mozdziak,
Dorota Bukowska,
Paweł Antosik,
Maciej Zabel,
Marzenna Podhorska-Okołów,
Piotr Dzięgiel,
Marta Szcześniak,
Maria Woszczyk,
Bartosz Kempisty

Affiliations

Katarzyna Stefańska: Cellivia 3 S.A., Poznan 60-529, Poland; Department of Histology and Embryology, Poznan University of Medical Sciences, Poznan 60-781, Poland
Ana Angelova Volponi: Centre for Craniofacial and Regenerative Biology, Dental Institute, King's College London, London WC2R 2LS, UK
Magdalena Kulus: Department of Veterinary Surgery, Institute of Veterinary Medicine, Nicolaus Copernicus University in Torun, Torun 87-100, Poland
Jadwiga Waśko: Cellivia 3 S.A., Poznan 60-529, Poland
Maryam Farzaneh: Fertility, Infertility and Perinatology Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
Joanna Grzelak: Division of Anatomy, Department of Human Morphology and Embryology, Faculty of Medicine, Wroclaw Medical University, Wroclaw 50-368, Poland; Correspondence to: Division of Anatomy, Department of Human Morphology and Embryology, Wroclaw Medical University, ul. T. Chalubinskiego 6a, Wroclaw 50-368, Poland.
Shirin Azizidoost: Atherosclerosis Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
Paul Mozdziak: Prestage Department of Poultry Sciences, North Carolina State University, Raleigh, NC 27695, USA
Dorota Bukowska: Department of Diagnostics and Clinical Sciences, Institute of Veterinary Medicine, Nicolaus Copernicus University in Torun, Torun 87-100, Poland
Paweł Antosik: Department of Veterinary Surgery, Institute of Veterinary Medicine, Nicolaus Copernicus University in Torun, Torun 87-100, Poland
Maciej Zabel: Division of Histology and Embryology, Department of Human Morphology and Embryology, Faculty of Medicine, Wroclaw Medical University, Wroclaw 50-368, Poland; Division of Anatomy and Histology, University of Zielona Góra, Zielona Góra 65-046, Poland
Marzenna Podhorska-Okołów: Division of Ultrastructural Research, Department of Human Morphology and Embryology, Wroclaw Medical University, Wroclaw 50-368, Poland
Piotr Dzięgiel: Division of Histology and Embryology, Department of Human Morphology and Embryology, Faculty of Medicine, Wroclaw Medical University, Wroclaw 50-368, Poland
Marta Szcześniak: Department of Diagnostics, Poznan University of Medical Sciences, Bukowska 70, Poznań 60-812, Poland; Department of Maxillofacial Surgery, Poznan University of Medical Sciences, Przybyszewskiego 49, Poznań 60-355, Poland
Maria Woszczyk: WSPL SP ZOZ; ul. Szylinga 1, Poznań, Poland
Bartosz Kempisty: Department of Veterinary Surgery, Institute of Veterinary Medicine, Nicolaus Copernicus University in Torun, Torun 87-100, Poland; Division of Anatomy, Department of Human Morphology and Embryology, Faculty of Medicine, Wroclaw Medical University, Wroclaw 50-368, Poland; College of Agriculture and Life Sciences, North Carolina State University, Raleigh, NC 27695, USA; Center of Assisted Reproduction, Department of Obstetrics and Gynecology, University Hospital and Masaryk University, Brno, Czech Republic

Journal volume & issue: Vol. 178
p. 116990

Abstract

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Dental pulp is a valuable and accessible source of stem cells (DPSCs) with characteristics similar to mesenchymal stem cells. DPSCs can regenerate a range of tissues and their potential for clinical application in regenerative medicine is promising. DPSCs have been found to express low levels of Class II HLA-DR (MHC) molecules, making them potential candidates for allogeneic transplantation without matching the donor's tissue. Research on the correlation between non-coding RNAs (ncRNAs) and human dental pulp stem cells (DPSCs) provides promising insights into the use of these cells in clinical settings for a wide range of medical conditions. It is possible to use a number of ncRNAs in order to restore the functional role of downregulated ncRNAs that are correlated with osteoblastogenesis, or to suppress the functional role of overexpressed ncRNAs associated with osteoclast differentiation in some cases.

Published in Biomedicine & Pharmacotherapy

ISSN: 0753-3322 (Print); 1950-6007 (Online)
Publisher: Elsevier
Country of publisher: France
LCC subjects: Medicine: Therapeutics. Pharmacology
Website: https://www.journals.elsevier.com/biomedicine-and-pharmacotherapy

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