LSD1: an emerging face in altering the tumor microenvironment and enhancing immune checkpoint therapy

M A A Mamun; Yu Zhang; Jin-Yuan Zhao; Dan-Dan Shen; Ting Guo; Yi-Chao Zheng; Li-Juan Zhao; Hong-Min Liu

doi:10.1186/s12929-023-00952-0

Journal of Biomedical Science (Jul 2023)

LSD1: an emerging face in altering the tumor microenvironment and enhancing immune checkpoint therapy

M A A Mamun,
Yu Zhang,
Jin-Yuan Zhao,
Dan-Dan Shen,
Ting Guo,
Yi-Chao Zheng,
Li-Juan Zhao,
Hong-Min Liu

Affiliations

M A A Mamun: Key Laboratory of Advanced Drug Preparation Technologies, Ministry of Education, China, State Key Laboratory of Esophageal Cancer Prevention and Treatment, Key Laboratory of Henan Province for Drug Quality and Evaluation, Institute of Drug Discovery and Development, School of Pharmaceutical Sciences, Zhengzhou University
Yu Zhang: Key Laboratory of Advanced Drug Preparation Technologies, Ministry of Education, China, State Key Laboratory of Esophageal Cancer Prevention and Treatment, Key Laboratory of Henan Province for Drug Quality and Evaluation, Institute of Drug Discovery and Development, School of Pharmaceutical Sciences, Zhengzhou University
Jin-Yuan Zhao: Key Laboratory of Advanced Drug Preparation Technologies, Ministry of Education, China, State Key Laboratory of Esophageal Cancer Prevention and Treatment, Key Laboratory of Henan Province for Drug Quality and Evaluation, Institute of Drug Discovery and Development, School of Pharmaceutical Sciences, Zhengzhou University
Dan-Dan Shen: Department of Obstetrics and Gynecology, The Third Affiliated Hospital of Zhengzhou University
Ting Guo: Key Laboratory of Advanced Drug Preparation Technologies, Ministry of Education, China, State Key Laboratory of Esophageal Cancer Prevention and Treatment, Key Laboratory of Henan Province for Drug Quality and Evaluation, Institute of Drug Discovery and Development, School of Pharmaceutical Sciences, Zhengzhou University
Yi-Chao Zheng: Key Laboratory of Advanced Drug Preparation Technologies, Ministry of Education, China, State Key Laboratory of Esophageal Cancer Prevention and Treatment, Key Laboratory of Henan Province for Drug Quality and Evaluation, Institute of Drug Discovery and Development, School of Pharmaceutical Sciences, Zhengzhou University
Li-Juan Zhao: Key Laboratory of Advanced Drug Preparation Technologies, Ministry of Education, China, State Key Laboratory of Esophageal Cancer Prevention and Treatment, Key Laboratory of Henan Province for Drug Quality and Evaluation, Institute of Drug Discovery and Development, School of Pharmaceutical Sciences, Zhengzhou University
Hong-Min Liu: Key Laboratory of Advanced Drug Preparation Technologies, Ministry of Education, China, State Key Laboratory of Esophageal Cancer Prevention and Treatment, Key Laboratory of Henan Province for Drug Quality and Evaluation, Institute of Drug Discovery and Development, School of Pharmaceutical Sciences, Zhengzhou University

DOI: https://doi.org/10.1186/s12929-023-00952-0
Journal volume & issue: Vol. 30, no. 1
pp. 1 – 18

Abstract

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Abstract Dysregulation of various cells in the tumor microenvironment (TME) causes immunosuppressive functions and aggressive tumor growth. In combination with immune checkpoint blockade (ICB), epigenetic modification-targeted drugs are emerging as attractive cancer treatments. Lysine-specific demethylase 1 (LSD1) is a protein that modifies histone and non-histone proteins and is known to influence a wide variety of physiological processes. The dysfunction of LSD1 contributes to poor prognosis, poor patient survival, drug resistance, immunosuppression, etc., making it a potential epigenetic target for cancer therapy. This review examines how LSD1 modulates different cell behavior in TME and emphasizes the potential use of LSD1 inhibitors in combination with ICB therapy for future cancer research studies.

Published in Journal of Biomedical Science

ISSN: 1021-7770 (Print); 1423-0127 (Online)
Publisher: BMC
Country of publisher: United Kingdom
LCC subjects: Medicine
Website: https://jbiomedsci.biomedcentral.com/

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Abstract

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