Nature Communications (Feb 2022)

Endogenous formaldehyde scavenges cellular glutathione resulting in redox disruption and cytotoxicity

  • Carla Umansky,
  • Agustín E. Morellato,
  • Matthias Rieckher,
  • Marco A. Scheidegger,
  • Manuela R. Martinefski,
  • Gabriela A. Fernández,
  • Oleg Pak,
  • Ksenia Kolesnikova,
  • Hernán Reingruber,
  • Mariela Bollini,
  • Gerry P. Crossan,
  • Natascha Sommer,
  • María Eugenia Monge,
  • Björn Schumacher,
  • Lucas B. Pontel

DOI
https://doi.org/10.1038/s41467-022-28242-7
Journal volume & issue
Vol. 13, no. 1
pp. 1 – 15

Abstract

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Formaldehyde (FA) is known to exert cytotoxicity through DNA damage. Here, the authors show that FA also triggers cellular redox imbalance by reacting with glutathione (GSH), and that FA cytotoxicity is prevented by GSH synthesis and by ADH5, an enzyme that metabolizes FA-GSH products.