Antibiotics (Jan 2017)

Fused-Ring Oxazolopyrrolopyridopyrimidine Systems with Gram-Negative Activity

  • Yiyuan Chen,
  • Jonathan G. Moloney,
  • Kirsten E. Christensen,
  • Mark G. Moloney

DOI
https://doi.org/10.3390/antibiotics6010002
Journal volume & issue
Vol. 6, no. 1
p. 2

Abstract

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Fused polyheterocyclic derivatives are available by annulation of a tetramate scaffold, and been shown to have antibacterial activity against a Gram-negative, but not a Gram-positive, bacterial strain. While the activity is not potent, these systems are structurally novel showing, in particular, a high level of polarity, and offer potential for the optimization of antibacterial activity.

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