Therapeutics and Clinical Risk Management (Dec 2018)

Incidence rate and risk factors of early repolarization in patients with growth hormone-secreting pituitary adenoma: a cohort study

  • Chen Z,
  • Hu B,
  • Feng Y,
  • Wang Z,
  • Jiang X,
  • Cheng Y,
  • He D,
  • Zhu D,
  • Xiao Z,
  • Wang H,
  • Mao Z

Journal volume & issue
Vol. Volume 15
pp. 65 – 72

Abstract

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Zhiyong Chen,1,2,* Bin Hu,1,* Yajuan Feng,3 Zongming Wang,1 Xiaobing Jiang,4 Yunjiu Cheng,5 Dongsheng He,1 Dimin Zhu,1 Zheng Xiao,1 Haijun Wang,1 Zhigang Mao1 1Department of Neurosurgery and Pituitary Tumor Center, The First Affiliated Hospital, SunYat-sen University, Guangzhou, People’s Republic of China; 2Department of Neurosurgery, The First Affiliated Hospital, Jinan University, Guangzhou, People’s Republic of China; 3Department of Histology and Embryology, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, People’s Republic of China; 4Department of Neurosurgery, Sun Yat-sen University Cancer Center, Guangzhou, People’s Republic of China; 5Department of Cardiology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, People’s Republic of China *These authors contributed equally to this work Purpose: To investigate the incidence and risk factors for early repolarization (ER) in patients with growth hormone (GH)-secreting pituitary adenomas. Methods: From August 2014 to August 2016, patients with GH-secreting pituitary adenomas and non-functioning pituitary adenomas admitted to the First Affiliated Hospital, Sun Yat-sen University, were prospectively enrolled. Logistic regression analysis was used to investigate risk factors for ER development. Results: A total of 118 patients with GH-secreting pituitary adenomas (41 with concomitant ER) and 103 patients with non-functioning pituitary adenomas were included. Compared with the non-functioning adenoma group GH and IGF-1 levels, left ventricular mass index (LVMI), and incidence of ER were significantly higher in the GH-secreting pituitary adenoma group (all P<0.05). LVMI was an independent risk factor for ER. Bivariate correlation analysis showed that course of disease, GH, IGF-1, and diabetes were correlated with LVMI. Course of disease and IGF-1 were directly correlated with LVMI. Two-year follow-up of patients who underwent transsphenoidal resection showed that incidence of ER was significantly decreased in patients with normal GH and IGF-1 levels. Conclusion: Compared with non-functioning pituitary adenoma patients, patients with GH-secreting pituitary adenomas have a significantly higher incidence of ER. Elevation of serum GH and IGF-1 had positive correlations with cardiac muscle cell hypertrophy and increased LVMI. Keywords: pituitary tumors, growth hormone-secreting pituitary adenoma, insulin-like growth factor, left ventricle mass index, early repolarization

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