DNA methyltransferase DNMT3a contributes to neuropathic pain by repressing Kcna2 in primary afferent neurons

Jian-Yuan Zhao; Lingli Liang; Xiyao Gu; Zhisong Li; Shaogen Wu; Linlin Sun; Fidelis E. Atianjoh; Jian Feng; Kai Mo; Shushan Jia; Brianna Marie Lutz; Alex Bekker; Eric J. Nestler; Yuan-Xiang Tao

doi:10.1038/ncomms14712

Nature Communications (Mar 2017)

DNA methyltransferase DNMT3a contributes to neuropathic pain by repressing Kcna2 in primary afferent neurons

Jian-Yuan Zhao,
Lingli Liang,
Xiyao Gu,
Zhisong Li,
Shaogen Wu,
Linlin Sun,
Fidelis E. Atianjoh,
Jian Feng,
Kai Mo,
Shushan Jia,
Brianna Marie Lutz,
Alex Bekker,
Eric J. Nestler,
Yuan-Xiang Tao

Affiliations

Jian-Yuan Zhao: Department of Anesthesiology, New Jersey Medical School, Rutgers, The State University of New Jersey
Lingli Liang: Department of Anesthesiology, New Jersey Medical School, Rutgers, The State University of New Jersey
Xiyao Gu: Department of Anesthesiology, New Jersey Medical School, Rutgers, The State University of New Jersey
Zhisong Li: Department of Anesthesiology, New Jersey Medical School, Rutgers, The State University of New Jersey
Shaogen Wu: Department of Anesthesiology, New Jersey Medical School, Rutgers, The State University of New Jersey
Linlin Sun: Department of Anesthesiology, New Jersey Medical School, Rutgers, The State University of New Jersey
Fidelis E. Atianjoh: Department of Anesthesiology, New Jersey Medical School, Rutgers, The State University of New Jersey
Jian Feng: Fishberg Department of Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai
Kai Mo: Department of Anesthesiology, New Jersey Medical School, Rutgers, The State University of New Jersey
Shushan Jia: Department of Anesthesiology, New Jersey Medical School, Rutgers, The State University of New Jersey
Brianna Marie Lutz: Department of Anesthesiology, New Jersey Medical School, Rutgers, The State University of New Jersey
Alex Bekker: Department of Anesthesiology, New Jersey Medical School, Rutgers, The State University of New Jersey
Eric J. Nestler: Fishberg Department of Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai
Yuan-Xiang Tao: Department of Anesthesiology, New Jersey Medical School, Rutgers, The State University of New Jersey

DOI: https://doi.org/10.1038/ncomms14712
Journal volume & issue: Vol. 8, no. 1
pp. 1 – 15

Abstract

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Transcriptional changes occur in the dorsal root ganglion in response to nerve injury and may contribute to neuropathic pain. Here the authors show that the DNA methyltransferase DNMT3a is upregulated in rodents following nerve injury, and may contribute to pain-like behaviour by decreasing expression of the voltage-gated potassium channel Kv1.2.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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