Possibility to use quanadex (dexmedetomidine) for caesarean section in patients with pre-eclampsia

Abstract

A prospective, double­blind, randomized, con­trolled clinical trial was conducted at the Republican Spe­cialized Scientific and Practical Medical Center of Obstet­rics and Gynecology of the Ministry of Health of the Repub­lic of Uzbekistan. The inclusion criteria for pregnant wom­en in the study was preeclampsia. All women were divided into 2 groups. In group I, premedication was performed on the table with sibazon 5 mg. In group II, starting from the moment of premedication, 0.5 µg/kg of quanadex (Yuriya Pharm) was administered intravenously for 15 minutes. The maintaining dose was 0.5–0.8 µg/kg/h. 0.5 % hyper­baric longocaine heavy was administered intrathecally at the LII–LIV level. Hemodynamics was assessed by echocardi­ography. BAC and electrolytes, lactate, glucose, hematocrit were studied on a gas analyzer “BGA­102” Wondfo (Rain Sen Da), NTproBNP, Cystatin­C, interleukin­6 and protein S­100 were determined on an immunofluorescence ana­lyzer Finecare™ FIA MeterPlus/FS 113 (Wonfo), sedation was assessed using the Richmond scale. Newborns were assessed for Apgar scores in the 1st and 5th minutes. The data obtained showed that patients randomized to the group with dexmedetomidine (Group II) were almost al­ways better able to awaken than patients in the group with sibazon, and were distinguished by better hemodynamic stability, antinociceptive protection for surgical and anes­thetic intervention, without pronounced arterial hypoten­sion and bradycardia. It did not cause significant adverse outcomes in newborns.

Keywords

• preeclampsia
• dexmedetomidine
• caesarean section