Nature Communications (Nov 2017)

Cisplatin is retained in the cochlea indefinitely following chemotherapy

  • Andrew M. Breglio,
  • Aaron E. Rusheen,
  • Eric D. Shide,
  • Katharine A. Fernandez,
  • Katie K. Spielbauer,
  • Katherine M. McLachlin,
  • Matthew D. Hall,
  • Lauren Amable,
  • Lisa L. Cunningham

DOI
https://doi.org/10.1038/s41467-017-01837-1
Journal volume & issue
Vol. 8, no. 1
pp. 1 – 9

Abstract

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Permanent hearing loss occurs in many cancer patients treated with cisplatin. In this study, the authors examine cisplatin pharmacokinetics in the cochleae of mice and humans showing that cisplatin is retained for months to years after treatment.