Mediterranean Journal of Hematology and Infectious Diseases (Jan 2011)

HHVs AND LYMPHOPROLIFERATIVE DISORDERS

  • G Riva,
  • P Barozzi,
  • C Quadrelli,
  • Mario Luppi

Journal volume & issue
Vol. 3, no. 1
pp. e2011043 – e2011043

Abstract

Read online

<p class="MsoNormal" style="text-align: justify; line-height: 200%; margin: 0cm 0cm 0pt; mso-layout-grid-align: none;"><span style="font-family: Times New Roman;"><span style="line-height: 200%; font-size: 10pt; mso-ansi-language: EN-US;" lang="EN-US">Epstein-Barr virus (EBV) is a &gamma; herpesvirus well recognized to be involved in the development of human B (Hodgkin and non Hodgkin lymphomas) and NK/T cell lymphomas, either in the general population or in the immunosuppressed individuals. The human herpesvirus 8 (HHV-8) is another &gamma; herpesvirus, recently recognized to be associated with the occurrence of rare B cell lymphomas and atypical lymphoproliferations, especially in the human immunodeficiency virus (HIV) infected subjects. Moreover, the human herpesvirus-6 (HHV-6), a </span><span style="line-height: 200%; font-size: 10pt;">&beta;</span><span style="line-height: 200%; font-size: 10pt; mso-ansi-language: EN-US;" lang="EN-US">-herpesvirus, has been shown to be implicated in some non-malignant lymph node proliferations, such as the Rosai Dorfman disease and in a proportion of Hodgkin lymphoma cases. HHV-6 has a wide cellular tropism and it might play a role in the pathogenesis of a wide variety of human diseases, but given its ubiquity, disease associations are difficult to prove and its role in hematological malignancies is still controversial. The involvement of another </span><span style="line-height: 200%; font-size: 10pt;">&beta;</span><span style="line-height: 200%; font-size: 10pt; mso-ansi-language: EN-US;" lang="EN-US">-herpesvirus, the human cytomegalovirus (HCMV), has not yet been proven in human cancer, even though recent findings have suggested its potential role in the development of CD4<sup>+</sup> large granular lymphocyte (LGL) lymphocytosis. Here, we review the current knowledge on the pathogenetic role of HHV-8 and human </span><span style="line-height: 200%; font-size: 10pt;">&beta;</span><span style="line-height: 200%; font-size: 10pt; mso-ansi-language: EN-US;" lang="EN-US">-herpesviruses in human lymphoproliferative disorders.</span></span></p>

Keywords