The minimal meningococcal ProQ protein has an intrinsic capacity for structure-based global RNA recognition

Saskia Bauriedl; Milan Gerovac; Nadja Heidrich; Thorsten Bischler; Lars Barquist; Jörg Vogel; Christoph Schoen

doi:10.1038/s41467-020-16650-6

Nature Communications (Jun 2020)

The minimal meningococcal ProQ protein has an intrinsic capacity for structure-based global RNA recognition

Saskia Bauriedl,
Milan Gerovac,
Nadja Heidrich,
Thorsten Bischler,
Lars Barquist,
Jörg Vogel,
Christoph Schoen

Affiliations

Saskia Bauriedl: Institute for Hygiene and Microbiology, University of Würzburg
Milan Gerovac: Institute for Molecular Infection Biology (IMIB), University of Würzburg
Nadja Heidrich: Institute for Molecular Infection Biology (IMIB), University of Würzburg
Thorsten Bischler: Institute for Molecular Infection Biology (IMIB), University of Würzburg
Lars Barquist: Helmholtz Institute for RNA-based Infection Research (HIRI), Helmholtz Centre for Infection Research (HZI)
Jörg Vogel: Institute for Molecular Infection Biology (IMIB), University of Würzburg
Christoph Schoen: Institute for Hygiene and Microbiology, University of Würzburg

DOI: https://doi.org/10.1038/s41467-020-16650-6
Journal volume & issue: Vol. 11, no. 1
pp. 1 – 15

Abstract

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FinO-domain proteins are bacterial RNA-binding proteins with a wide range of target specificities. Here, the authors employ UV CLIP-seq and show that minimal ProQ protein of Neisseria meningitidis binds to various small non-coding RNAs and mRNAs involved in virulence.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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