Using dates (Phoenix dactylifera l.) to improve energy metabolism in fatigue-induced Sprague Dawley rats
Hana Kadum,
Azizah Hamid,
Faridah Abas,
Nurul Shazini Ramli,
Ahmad Haniff Jaafar,
Mohd Sabri Pak Dek,
Belal J. Muhialdin,
Hani Hafeeza Halim,
Abdul Karim Sabo Mohammed,
Salam A. Ibrahim
Affiliations
Hana Kadum
Department of Food Science, Faculty of Food Science and Technology, UPM Serdang, Universiti Putra Malaysia, Selangor 43400, Malaysia; Faculty of Science, Al-Muthanna University, Iraq
Azizah Hamid
Department of Food Science, Faculty of Food Science and Technology, UPM Serdang, Universiti Putra Malaysia, Selangor 43400, Malaysia; Corresponding author.
Faridah Abas
Department of Food Science, Faculty of Food Science and Technology, UPM Serdang, Universiti Putra Malaysia, Selangor 43400, Malaysia; Institute of Bioscience, UPM Serdang, Universiti Putra Malaysia, Selangor 43400, Malaysia
Nurul Shazini Ramli
Department of Food Science, Faculty of Food Science and Technology, UPM Serdang, Universiti Putra Malaysia, Selangor 43400, Malaysia
Ahmad Haniff Jaafar
Department of Food Science, Faculty of Food Science and Technology, UPM Serdang, Universiti Putra Malaysia, Selangor 43400, Malaysia; Corresponding author.
Mohd Sabri Pak Dek
Department of Food Science, Faculty of Food Science and Technology, UPM Serdang, Universiti Putra Malaysia, Selangor 43400, Malaysia
Belal J. Muhialdin
Department of Food Science, Faculty of Food Science and Technology, UPM Serdang, Universiti Putra Malaysia, Selangor 43400, Malaysia; Halal Products Research Institute, UPM Serdang, Universiti Putra Malaysia, Selangor 43400, Malaysia
Hani Hafeeza Halim
Department of Food Science, Faculty of Food Science and Technology, UPM Serdang, Universiti Putra Malaysia, Selangor 43400, Malaysia
Abdul Karim Sabo Mohammed
Department of Food Science, Faculty of Food Science and Technology, UPM Serdang, Universiti Putra Malaysia, Selangor 43400, Malaysia; Faculty of Science, The Federal University of Dutse, Dutse, Jigawa, Nigeria
Salam A. Ibrahim
Food and Nutritional Sciences Program, North Carolina A&T State University, Greensboro, NC 27411, USA
Fatigue increases oxidative stress which damages body cells and increases the risk for the development of various chronic diseases. In this study, the anti-fatigue activity of Piyarom date extract was evaluated in fatigue-induced rats using a forced swimming test (FST). Results showed that rats treated with 500 mg/kg BW date extract exhibited enhanced energy production with a highest endurance capacity (632.9±28.7 min). The date-treated rats also had lower blood lactate, indicating efficient energy utilization with lower fatigue as compared to normal and fatigued rats. Moreover, the serum lactate dehydrogenase levels in 250 and 500 mg/kg BW date extracts and caffeine groups were significantly lower compared to the fatigued rats. Creatine kinase activity was the lowest in the group fed with 500 mg/kg BW date extract. The treated rats showed an amelioration of lipid profiles, while the histological study revealed improvement in various organs. Rats treated with 500 mg/kg BW date extract demonstrated an enhancement in energy production and improved energy metabolism which could be due to the presence of bioactive compounds in the dates. Piyarom date extract demonstrated anti-fatigue property and could be used as a functional ingredient in the development of beverages or snacks that address fatigue associated maladies.
