Nature Communications (Apr 2019)

Self-organization of Plk4 regulates symmetry breaking in centriole duplication

  • Shohei Yamamoto,
  • Daiju Kitagawa

DOI
https://doi.org/10.1038/s41467-019-09847-x
Journal volume & issue
Vol. 10, no. 1
pp. 1 – 12

Abstract

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During centriole duplication, Plk4 regulates formation of a single daughter centriole adjacent to the mother centriole, but the mechanism is unclear. Here, the authors show that Plk4 can undergo liquid–liquid phase separation and that the condensation properties are regulated by autophosphorylation.