A Case–Control Study on Behavioral Addictions and Neurocognition: Description of the BANCO and BANCO2 Protocols

Abstract

Elodie Hurel,1,2 Marie Grall-Bronnec,1,2 Elsa Thiabaud,1 Anaïs Saillard,1 Jean-Benoît Hardouin,2 Gaëlle Challet-Bouju1,2 1CHU Nantes, Addictology and Psychiatry Department, Nantes, France; 2INSERM U1246 SPHERE (methodS in Patient-centered outcomes & HEalth ResEarch), University of Nantes, University of Tours, Nantes, FranceCorrespondence: Gaëlle Challet-Bouju Email [email protected]: Only two behavioral addictions (BAs) are currently recognized in international classifications (gambling disorder: GbD; gaming disorder: GmD), while some of them await further investigation (food addiction: FA; sexual addiction: SA). Neurocognitive functioning is considered a risk factor for BAs. Research is quite abundant for GbD and highlights specific deficits in several cognitive functions. Nevertheless, grey areas still exist. The aim of this research programme is to investigate the neurocognitive profiles of patients presenting with various BAs and to establish parallels between different forms of BA to achieve a common addiction concept.Methods and Analysis: This research program is composed of two studies sharing the same methodology but focusing on different samples: the BANCO study aims to include 30 individuals with a GbD, whereas the BANCO2 study aims to include 30 individuals with a GmD, 30 with a SA, and 30 with a FA. Moreover, for each BA group, 30 healthy controls will be recruited, matched by sex, age and education level. Several cognitive tasks will be completed by participants. Cue reactivity and physiological responses, as well as clinical data regarding addiction characteristics and personality, will also be investigated. A composite score based on the cognitive tasks will be computed using principal component analysis (PCA). Overall cognitive performance and detailed performance on the different cognitive tasks will be compared between individuals with BAs and their matched healthy controls using linear models with random effects. Comparisons will also be made between BA groups to investigate specific alterations associated with each disorder.Discussion: The results of this research programme will impact both research and clinical areas by (i) providing new knowledge for discussions regarding the inclusion of BAs under the spectrum of addictive disorders; (ii) improving understanding of addiction mechanisms in general; (iii) providing clarity in the grey areas in neurocognitive research on BAs and improving the understanding of less studied BAs, (iv) guiding clinicians to propose therapeutic alternatives and complementary programmes.Trial Registration: BANCO study (ClinicalTrials.gov NCT03202290); BANCO2 study (ClinicalTrials.gov NCT03967418).Keywords: behavioral addiction, neurocognition, neuropsychology, gaming disorder, gambling disorder, sexual addiction, food addiction

Keywords

• behavioral addiction – neurocognition – neuropsychology – gaming disorder – gambling disorder – sexual addiction – food addiction