Requirements Analysis and Specification for a Molecular Tumor Board Platform Based on cBioPortal
Philipp Buechner,
Marc Hinderer,
Philipp Unberath,
Patrick Metzger,
Martin Boeker,
Till Acker,
Florian Haller,
Elisabeth Mack,
Daniel Nowak,
Claudia Paret,
Denny Schanze,
Nikolas von Bubnoff,
Sebastian Wagner,
Hauke Busch,
Melanie Boerries,
Jan Christoph
Affiliations
Philipp Buechner
Department of Medical Informatics, Friedrich-Alexander-University Erlangen-Nürnberg (FAU), 91058 Erlangen-Tennenlohe, Germany
Marc Hinderer
Department of Medical Informatics, Friedrich-Alexander-University Erlangen-Nürnberg (FAU), 91058 Erlangen-Tennenlohe, Germany
Philipp Unberath
Department of Medical Informatics, Friedrich-Alexander-University Erlangen-Nürnberg (FAU), 91058 Erlangen-Tennenlohe, Germany
Patrick Metzger
Institute of Medical Bioinformatics and Systems Medicine, Faculty of Medicine and Medical Center-University of Freiburg, 79110 Freiburg, Germany
Martin Boeker
Institute of Medical Biometry and Statistics, Faculty of Medicine and Medical Center, University of Freiburg, 79104 Freiburg, Germany
Till Acker
Institute of Neuropathology, Justus-Liebig-University Giessen, 35392 Giessen, Germany
Florian Haller
Institute of Pathology, University Hospital Erlangen, 91054 Erlangen, Germany
Elisabeth Mack
Department of Hematology, Oncology and Immunology, Philipps-University Marburg, and University Hospital Gießen and Marburg, Marburg, Germany Baldingerstraße, 35043 Marburg, Germany
Daniel Nowak
Department of Hematology and Oncology, Medical Faculty Mannheim, Heidelberg University, 68167 Mannheim, Germany
Claudia Paret
Pediatric Hematology/Oncology, Children’s Hospital, University Medical Center of the Johannes Gutenberg-University Mainz, 55131 Mainz, Germany
Denny Schanze
Institute of Human Genetics, University Hospital Magdeburg, Faculty of Medicine, Otto-von-Guericke University, 39120 Magdeburg, Germany
Nikolas von Bubnoff
Department of Hematology and Oncology, Medical Center, University of Schleswig-Holstein, Campus Lübeck, 23538 Lübeck, Germany
Sebastian Wagner
Department of Medicine 2, Hematology/Oncology, Goethe University Hospital, 60590 Frankfurt am Main, Germany
Hauke Busch
Institute of Experimental Dermatology and Institute of Cardiogenetics, University of Lübeck, 23562 Lübeck, Germany
Melanie Boerries
Institute of Medical Bioinformatics and Systems Medicine, Faculty of Medicine and Medical Center-University of Freiburg, 79110 Freiburg, Germany
Jan Christoph
Department of Medical Informatics, Friedrich-Alexander-University Erlangen-Nürnberg (FAU), 91058 Erlangen-Tennenlohe, Germany
Clinicians in molecular tumor boards (MTB) are confronted with a growing amount of genetic high-throughput sequencing data. Today, at German university hospitals, these data are usually handled in complex spreadsheets from which clinicians have to obtain the necessary information. The aim of this work was to gather a comprehensive list of requirements to be met by cBioPortal to support processes in MTBs according to clinical needs. Therefore, oncology experts at nine German university hospitals were surveyed in two rounds of interviews. To generate an interview guideline a scoping review was conducted. For visual support in the second round, screenshot mockups illustrating the requirements from the first round were created. Requirements that cBioPortal already meets were skipped during the second round. In the end, 24 requirements with sometimes several conceivable options were identified and 54 screenshot mockups were created. Some of the identified requirements have already been suggested to the community by other users or are currently being implemented in cBioPortal. This shows, that the results are in line with the needs expressed by various disciplines. According to our findings, cBioPortal has the potential to significantly improve the processes and analyses of an MTB after the implementation of the identified requirements.