Nature Communications (Nov 2017)
A comprehensive structural, biochemical and biological profiling of the human NUDIX hydrolase family
- Jordi Carreras-Puigvert,
- Marinka Zitnik,
- Ann-Sofie Jemth,
- Megan Carter,
- Judith E. Unterlass,
- Björn Hallström,
- Olga Loseva,
- Zhir Karem,
- José Manuel Calderón-Montaño,
- Cecilia Lindskog,
- Per-Henrik Edqvist,
- Damian J. Matuszewski,
- Hammou Ait Blal,
- Ronnie P. A. Berntsson,
- Maria Häggblad,
- Ulf Martens,
- Matthew Studham,
- Bo Lundgren,
- Carolina Wählby,
- Erik L. L. Sonnhammer,
- Emma Lundberg,
- Pål Stenmark,
- Blaz Zupan,
- Thomas Helleday
Affiliations
- Jordi Carreras-Puigvert
- Division of Translational Medicine and Chemical Biology, Science for Life Laboratory, Department of Molecular Biochemistry and Biophysics, Karolinska Institutet
- Marinka Zitnik
- Faculty of Computer and Information Science, University of Ljubljana
- Ann-Sofie Jemth
- Division of Translational Medicine and Chemical Biology, Science for Life Laboratory, Department of Molecular Biochemistry and Biophysics, Karolinska Institutet
- Megan Carter
- Department of Biochemistry and Biophysics, Stockholm University
- Judith E. Unterlass
- Division of Translational Medicine and Chemical Biology, Science for Life Laboratory, Department of Molecular Biochemistry and Biophysics, Karolinska Institutet
- Björn Hallström
- Cell Profiling—Affinity Proteomics, Science for Life Laboratory, KTH—Royal Institute of Technology
- Olga Loseva
- Division of Translational Medicine and Chemical Biology, Science for Life Laboratory, Department of Molecular Biochemistry and Biophysics, Karolinska Institutet
- Zhir Karem
- Division of Translational Medicine and Chemical Biology, Science for Life Laboratory, Department of Molecular Biochemistry and Biophysics, Karolinska Institutet
- José Manuel Calderón-Montaño
- Division of Translational Medicine and Chemical Biology, Science for Life Laboratory, Department of Molecular Biochemistry and Biophysics, Karolinska Institutet
- Cecilia Lindskog
- Department of Immunology, Genetics and Pathology, Science for Life Laboratory
- Per-Henrik Edqvist
- Department of Immunology, Genetics and Pathology, Science for Life Laboratory
- Damian J. Matuszewski
- Centre for Image Analysis and Science for Life Laboratory, Uppsala University
- Hammou Ait Blal
- Cell Profiling—Affinity Proteomics, Science for Life Laboratory, KTH—Royal Institute of Technology
- Ronnie P. A. Berntsson
- Department of Biochemistry and Biophysics, Stockholm University
- Maria Häggblad
- Biochemical and Cellular Screening Facility, Science for Life Laboratory, Department of Biochemistry and Biophysics, Stockholm University
- Ulf Martens
- Biochemical and Cellular Screening Facility, Science for Life Laboratory, Department of Biochemistry and Biophysics, Stockholm University
- Matthew Studham
- Stockholm Bioinformatics Center, Science for Life Laboratory, Department of Biochemistry and Biophysics, Stockholm University
- Bo Lundgren
- Biochemical and Cellular Screening Facility, Science for Life Laboratory, Department of Biochemistry and Biophysics, Stockholm University
- Carolina Wählby
- Centre for Image Analysis and Science for Life Laboratory, Uppsala University
- Erik L. L. Sonnhammer
- Stockholm Bioinformatics Center, Science for Life Laboratory, Department of Biochemistry and Biophysics, Stockholm University
- Emma Lundberg
- Cell Profiling—Affinity Proteomics, Science for Life Laboratory, KTH—Royal Institute of Technology
- Pål Stenmark
- Department of Biochemistry and Biophysics, Stockholm University
- Blaz Zupan
- Faculty of Computer and Information Science, University of Ljubljana
- Thomas Helleday
- Division of Translational Medicine and Chemical Biology, Science for Life Laboratory, Department of Molecular Biochemistry and Biophysics, Karolinska Institutet
- DOI
- https://doi.org/10.1038/s41467-017-01642-w
- Journal volume & issue
-
Vol. 8,
no. 1
pp. 1 – 17
Abstract
The NUDIX hydrolases are known to be involved in several cellular processes and diseases, such as cancer, but remain poorly characterized as a family. Here, the authors provide a comprehensive analysis of the structural, biochemical, and expression properties of 18 human NUDIX proteins, and begin to address their functional inter-relationships.
