MODERN TECHNOLOGIES IN THERAPEUTIC DRUG MONITORING (REVIEW)

Abstract

Abstract: due to the emergence of new technologies in a pharmakokinetics, a pharmacogenetics and analytical chemistry, the medicine comes to qualitatively new stage of development. Therapeutic drug monitoring as the mean of the real time pharmacotherapy efficiency control becomes the basis of rational therapy in modern medicine. In the article various aspects of the therapeutic drug monitoring (TDM) as subsection of clinical pharmacology are discussed. The main indications to carrying out TDM and the main TDM procedures are submitted. Value of TDM for an epileptology is discussed. The special attention is paid to the bioanalytical methods and new methodical approaches (such as non-invasive drug monitoring and equilibrium dialysis) applied in TDM. TDM role as an independent discipline of a medical sciences, with concentration on modern pharmacokinetics computer programs is separately analyzed.

Keywords

• therapeutic drug monitoring
• antiepileptic drug
• free and bound fractions of a preparation
• equilibrium dialysis
• pharmacogenetics testing
• non-invasive tdm
• chromatography
• mass spectrometry
• population pharmacokinetic computer modeling
• drug-drug interactions