Nature Communications (May 2016)
HIF-1α-PDK1 axis-induced active glycolysis plays an essential role in macrophage migratory capacity
- Hiroaki Semba,
- Norihiko Takeda,
- Takayuki Isagawa,
- Yuki Sugiura,
- Kurara Honda,
- Masaki Wake,
- Hidenobu Miyazawa,
- Yoshifumi Yamaguchi,
- Masayuki Miura,
- Dana M. R. Jenkins,
- Hyunsung Choi,
- Jung-whan Kim,
- Masataka Asagiri,
- Andrew S. Cowburn,
- Hajime Abe,
- Katsura Soma,
- Katsuhiro Koyama,
- Manami Katoh,
- Keimon Sayama,
- Nobuhito Goda,
- Randall S. Johnson,
- Ichiro Manabe,
- Ryozo Nagai,
- Issei Komuro
Affiliations
- Hiroaki Semba
- Department of Cardiovascular Medicine, Graduate School of Medicine, The University of Tokyo
- Norihiko Takeda
- Department of Cardiovascular Medicine, Graduate School of Medicine, The University of Tokyo
- Takayuki Isagawa
- Department of Cardiovascular Medicine, Graduate School of Medicine, The University of Tokyo
- Yuki Sugiura
- PRESTO, JST
- Kurara Honda
- Department of Biochemistry, Keio University School of Medicine
- Masaki Wake
- Department of Cardiovascular Medicine, Graduate School of Medicine, The University of Tokyo
- Hidenobu Miyazawa
- Department of Genetics, Graduate School of Pharmaceutical Sciences, The University of Tokyo
- Yoshifumi Yamaguchi
- PRESTO, JST
- Masayuki Miura
- Department of Genetics, Graduate School of Pharmaceutical Sciences, The University of Tokyo
- Dana M. R. Jenkins
- Department of Biological Sciences, The University of Texas at Dallas
- Hyunsung Choi
- Department of Biological Sciences, The University of Texas at Dallas
- Jung-whan Kim
- Department of Biological Sciences, The University of Texas at Dallas
- Masataka Asagiri
- Innovation Center for Immunoregulation and Therapeutics, Graduate School of Medicine, Kyoto University
- Andrew S. Cowburn
- Department of Physiology, Development and Neuroscience, University of Cambridge
- Hajime Abe
- Department of Cardiovascular Medicine, Graduate School of Medicine, The University of Tokyo
- Katsura Soma
- Department of Cardiovascular Medicine, Graduate School of Medicine, The University of Tokyo
- Katsuhiro Koyama
- Department of Cardiovascular Medicine, Graduate School of Medicine, The University of Tokyo
- Manami Katoh
- Department of Cardiovascular Medicine, Graduate School of Medicine, The University of Tokyo
- Keimon Sayama
- Department of Life Science and Medical BioScience, School of Advanced Science and Engineering, Waseda University
- Nobuhito Goda
- Department of Life Science and Medical BioScience, School of Advanced Science and Engineering, Waseda University
- Randall S. Johnson
- Department of Physiology, Development and Neuroscience, University of Cambridge
- Ichiro Manabe
- Department of Cardiovascular Medicine, Graduate School of Medicine, The University of Tokyo
- Ryozo Nagai
- Jichi Medical University
- Issei Komuro
- Department of Cardiovascular Medicine, Graduate School of Medicine, The University of Tokyo
- DOI
- https://doi.org/10.1038/ncomms11635
- Journal volume & issue
-
Vol. 7,
no. 1
pp. 1 – 10
Abstract
Migration to the inflamed tissue demands energy production in an increasingly hypoxic environment. Here the authors show that during migration, HIF1α-induced PDK1 uniquely adapts macrophage metabolism to mild hypoxia by promoting glycolysis while preserving cytochrome c oxidase activity.
