Dephosphorylated parafibromin is a transcriptional coactivator of the Wnt/Hedgehog/Notch pathways

Ippei Kikuchi; Atsushi Takahashi-Kanemitsu; Natsuki Sakiyama; Chao Tang; Pei-Jung Tang; Saori Noda; Kazuki Nakao; Hidetoshi Kassai; Toshiro Sato; Atsu Aiba; Masanori Hatakeyama

doi:10.1038/ncomms12887

Nature Communications (Sep 2016)

Dephosphorylated parafibromin is a transcriptional coactivator of the Wnt/Hedgehog/Notch pathways

Ippei Kikuchi,
Atsushi Takahashi-Kanemitsu,
Natsuki Sakiyama,
Chao Tang,
Pei-Jung Tang,
Saori Noda,
Kazuki Nakao,
Hidetoshi Kassai,
Toshiro Sato,
Atsu Aiba,
Masanori Hatakeyama

Affiliations

Ippei Kikuchi: Division of Microbiology, Graduate School of Medicine, The University of Tokyo
Atsushi Takahashi-Kanemitsu: Division of Microbiology, Graduate School of Medicine, The University of Tokyo
Natsuki Sakiyama: Division of Microbiology, Graduate School of Medicine, The University of Tokyo
Chao Tang: Division of Microbiology, Graduate School of Medicine, The University of Tokyo
Pei-Jung Tang: Division of Microbiology, Graduate School of Medicine, The University of Tokyo
Saori Noda: Division of Microbiology, Graduate School of Medicine, The University of Tokyo
Kazuki Nakao: Laboratory of Animal Resources, Center for Disease Biology and Integrative Medicine, Graduate School of Medicine, The University of Tokyo
Hidetoshi Kassai: Laboratory of Animal Resources, Center for Disease Biology and Integrative Medicine, Graduate School of Medicine, The University of Tokyo
Toshiro Sato: Division of Gastroenterology, Keio University School of Medicine
Atsu Aiba: Laboratory of Animal Resources, Center for Disease Biology and Integrative Medicine, Graduate School of Medicine, The University of Tokyo
Masanori Hatakeyama: Division of Microbiology, Graduate School of Medicine, The University of Tokyo

DOI: https://doi.org/10.1038/ncomms12887
Journal volume & issue: Vol. 7, no. 1
pp. 1 – 15

Abstract

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Normal epithelial intestine organisation requires Wnt and Hedgehog signalling activity. Here, the authors show that parafibromin can activate both pathways in a mutually exclusive manner and is important for intestinal homeostasis.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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