Double Case Control Study on Effect of Ibuprofen and Acetaminophen in Premature Neonate with Patent Ductus Arteriosus in Neonatal Intensive Care Unit in Sulaimania Maternity Hospital

Abstract

Backgrounds and objectives:Persistent patency of the ductus arteriosus is a major cause of morbidity and mortality in premature infants. Cyclooxygenase inhibitors remain the mainstay of medical therapy for patent ductus arteriosus. The aim of this study is to evaluate pharmacological closures of Patent Ductus Artriosus in premature babies. Patients and Methods:Double case control study done on sixty premature neonates with a gestational age (25-37) weeks, who were admitted to the Sulaimania maternity hospital from February to September 2017. Patent ductus artriosus diagnosis was confirmed by echocardiography. Twenty neonates received oral ibuprofen, an initial dose of 20mg/kg, followed by 10mg/kg at 24 or 48 hours later, twenty cases received oral acetaminophen in dose of 20mg/kg as initial dose, followed by 15mg/kg every eight hours for 3 days. Twenty cases not received treatment after taking consent from their family. The second echo was done after completed treatment. Results: In sixty premature neonates with patent ductus arteriosus; twenty cases received ibuprofen 14 cases responded to the treatment (70%), and 7 cases (35%) developed side effects, twenty cases received acetaminophen 11 cases responded to the treatment (55%), and side effects developed in just 3 cases (15%). lastly twenty cases received no treatment patent ducts arteriosus closed in just 8 cases (40%). Conclusions: Ibuprofen is slightly more effective on the closing of the PDA in preterm infants than acetaminophen, but the latter has fewer side effects and using medication is preferred on using no medication

Keywords

• Patent ductus arteriosus
• Ibuprofen
• Acetaminophen
• Premature neonates