Chemical Modification of the siRNA Seed Region Suppresses Off-Target Effects by Steric Hindrance to Base-Pairing with Targets

• Hanna Iribe,
• Kengo Miyamoto,
• Tomoko Takahashi,
• Yoshiaki Kobayashi,
• Jastina Leo,
• Misako Aida,
• Kumiko Ui-Tei

Affiliations

Hanna Iribe

Department of Computational Biology and Medical Science, Graduate School of Frontier Sciences, The University of Tokyo, Chiba, Japan

Kengo Miyamoto

Center for Quantum Life Sciences and Department of Chemistry, Graduate School of Science, Hiroshima University, Higashi-Hiroshima, Japan

Tomoko Takahashi

Department of Biological Sciences, Graduate School of Science, The University of Tokyo, Tokyo, Japan

Yoshiaki Kobayashi

Department of Biological Sciences, Graduate School of Science, The University of Tokyo, Tokyo, Japan

Jastina Leo

Department of Biological Sciences, Graduate School of Science, The University of Tokyo, Tokyo, Japan

Misako Aida

Center for Quantum Life Sciences and Department of Chemistry, Graduate School of Science, Hiroshima University, Higashi-Hiroshima, Japan

Kumiko Ui-Tei

Department of Computational Biology and Medical Science, Graduate School of Frontier Sciences, The University of Tokyo, Chiba, Japan