The methyltransferase Suv39h1 links the SUMO pathway to HP1α marking at pericentric heterochromatin

Abstract

The Suv39h histone methyltransferases promote trimethylation of histone H3 on lysine 9 (H3K9me3). Here, in the Suv39h1 paralog, the authors identify an enhancer of HP1a sumoylation activity that impacts heterochromatin.