CPT: Pharmacometrics & Systems Pharmacology (Nov 2014)

Physiologically Based Pharmacokinetic Modeling and Simulation in Pediatric Drug Development

  • A R Maharaj,
  • A N Edginton

DOI
https://doi.org/10.1038/psp.2014.45
Journal volume & issue
Vol. 3, no. 11
pp. 1 – 13

Abstract

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Increased regulatory demands for pediatric drug development research have fostered interest in the use of modeling and simulation among industry and academia. Physiologically based pharmacokinetic (PBPK) modeling offers a unique modality to incorporate multiple levels of information to estimate age‐specific pharmacokinetics. This tutorial will serve to provide the reader with a basic understanding of the procedural steps to developing a pediatric PBPK model and facilitate a discussion of the advantages and limitations of this modeling technique. CPT Pharmacometrics Syst. Pharmacol. (2014) 3, e148; doi:10.1038/psp.2014.45; published online 19 November 2014