Proceedings
(Aug 2019)
Synthesis of Enantiomeric Halolactones with Aromatic Ring, Their Anticancer Activity and Interactions with Biological Membranes
Witold Gładkowski,
Aleksandra Pawlak,
Aleksandra Włoch,
Marcelina Mazur,
Halina Kleszczyńska,
Bożena Obmińska-Mrukowicz
Affiliations
Witold Gładkowski
Department of Chemistry, Wrocław University of Environmental and Life Sciences, Norwida 25, 50-375 Wrocław, Poland
Aleksandra Pawlak
Department of Pharmacology and Toxicology, Wrocław University of Environmental and Life Sciences, Norwida 31, 50-375 Wrocław, Poland
Aleksandra Włoch
Department of Physics and Biophysics, Wrocław University of Environmental and Life Sciences, Norwida 25, 50-375 Wrocław, Poland
Marcelina Mazur
Department of Chemistry, Wrocław University of Environmental and Life Sciences, Norwida 25, 50-375 Wrocław, Poland
Halina Kleszczyńska
Department of Physics and Biophysics, Wrocław University of Environmental and Life Sciences, Norwida 25, 50-375 Wrocław, Poland
Bożena Obmińska-Mrukowicz
Department of Pharmacology and Toxicology, Wrocław University of Environmental and Life Sciences, Norwida 31, 50-375 Wrocław, Poland
DOI
https://doi.org/10.3390/proceedings2019022047
Journal volume & issue
Vol. 22,
no. 1
Abstract
Read online
Studying the effect of chirality on the activity of tested compounds, we synthesized new series of the enantiomeric (ee = 98–100%) β-aryl-δ-halo-γ-lactones with defined configurations of stereogenic centers. [...]
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