Synthesis and Photolytic Assessment of Nitroindolinyl-Caged Calcium Ion Chelators

Abstract

Neuroactive amino acids derivatised at their carboxylate groups with a photolabile nitroindolinyl group are highly effective reagents for the sub-µs release of neuroactive amino acids in physiological solutions. However, the same does not apply in the case of calcium ion chelators. In this study, nitroindolinyl-caged BAPTA is found to be completely photostable, whereas nitroindolinyl-caged EDTA photolyses only when saturated with calcium ions.

Keywords

• nitroindoline cages
• calcium chelators
• chemical synthesis
• photolysis
• photostability