Nature Communications (Sep 2016)
Mutational signatures of ionizing radiation in second malignancies
- Sam Behjati,
- Gunes Gundem,
- David C. Wedge,
- Nicola D. Roberts,
- Patrick S. Tarpey,
- Susanna L. Cooke,
- Peter Van Loo,
- Ludmil B. Alexandrov,
- Manasa Ramakrishna,
- Helen Davies,
- Serena Nik-Zainal,
- Claire Hardy,
- Calli Latimer,
- Keiran M. Raine,
- Lucy Stebbings,
- Andy Menzies,
- David Jones,
- Rebecca Shepherd,
- Adam P. Butler,
- Jon W. Teague,
- Mette Jorgensen,
- Bhavisha Khatri,
- Nischalan Pillay,
- Adam Shlien,
- P. Andrew Futreal,
- Christophe Badie,
- ICGC Prostate Group,
- Ultan McDermott,
- G. Steven Bova,
- Andrea L. Richardson,
- Adrienne M. Flanagan,
- Michael R. Stratton,
- Peter J. Campbell
Affiliations
- Sam Behjati
- Cancer Genome Project, Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus
- Gunes Gundem
- Cancer Genome Project, Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus
- David C. Wedge
- Cancer Genome Project, Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus
- Nicola D. Roberts
- Cancer Genome Project, Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus
- Patrick S. Tarpey
- Cancer Genome Project, Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus
- Susanna L. Cooke
- Cancer Genome Project, Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus
- Peter Van Loo
- The Francis Crick Institute
- Ludmil B. Alexandrov
- Cancer Genome Project, Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus
- Manasa Ramakrishna
- Cancer Genome Project, Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus
- Helen Davies
- Cancer Genome Project, Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus
- Serena Nik-Zainal
- Cancer Genome Project, Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus
- Claire Hardy
- Cancer Genome Project, Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus
- Calli Latimer
- Cancer Genome Project, Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus
- Keiran M. Raine
- Cancer Genome Project, Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus
- Lucy Stebbings
- Cancer Genome Project, Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus
- Andy Menzies
- Cancer Genome Project, Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus
- David Jones
- Cancer Genome Project, Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus
- Rebecca Shepherd
- Cancer Genome Project, Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus
- Adam P. Butler
- Cancer Genome Project, Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus
- Jon W. Teague
- Cancer Genome Project, Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus
- Mette Jorgensen
- University College London Cancer Institute
- Bhavisha Khatri
- Histopathology, Royal National Orthopaedic Hospital NHS Trust
- Nischalan Pillay
- University College London Cancer Institute
- Adam Shlien
- Cancer Genome Project, Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus
- P. Andrew Futreal
- Cancer Genome Project, Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus
- Christophe Badie
- Radiation Effects Department, Cancer Mechanisms and Biomarkers Group, Centre for Radiation Chemical and Environmental Hazards, Public Health England
- ICGC Prostate Group
- Ultan McDermott
- Cancer Genome Project, Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus
- G. Steven Bova
- Institute of Biosciences and Medical Technology, BioMediTech, University of Tampere and Fimlab Laboratories, Tampere University Hospital
- Andrea L. Richardson
- Dana-Farber Cancer Institute
- Adrienne M. Flanagan
- University College London Cancer Institute
- Michael R. Stratton
- Cancer Genome Project, Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus
- Peter J. Campbell
- Cancer Genome Project, Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus
- DOI
- https://doi.org/10.1038/ncomms12605
- Journal volume & issue
-
Vol. 7,
no. 1
pp. 1 – 8
Abstract
Ionizing radiation may induce irreparable DNA damage leading to cancer. Here, the authors identify a specific signature of mutations arising in patients exposed to ionizing radiation and suggest that radiation-induced tumorigenesis is associated with higher rates of genome-wide deletions and balanced inversions.
