Developmental Mutators and Early Onset Cancer

Alex Kentsis; Steven A. Frank

doi:10.3389/fped.2020.00189

Frontiers in Pediatrics (Apr 2020)

Developmental Mutators and Early Onset Cancer

Alex Kentsis,
Steven A. Frank

Affiliations

Alex Kentsis: Sloan Kettering Institute and Department of Pediatrics, Weill Medical College of Cornell University and Memorial Sloan Kettering Cancer Center, New York, NY, United States
Steven A. Frank: Department of Ecology and Evolutionary Biology, University of California, Irvine, Irvine, CA, United States

DOI: https://doi.org/10.3389/fped.2020.00189
Journal volume & issue: Vol. 8

Abstract

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A new hypothesis suggests that somatic genome remodeling during normal development can cause mutations that explain many early onset cancers in children and adults.

Published in Frontiers in Pediatrics

ISSN: 2296-2360 (Online)
Publisher: Frontiers Media S.A.
Country of publisher: Switzerland
LCC subjects: Medicine: Pediatrics
Website: http://journal.frontiersin.org/journal/pediatrics

About the journal

Abstract

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