Trends of Laryngeal Cancer Incidence and Mortality in China，2005—2016

Abstract

BackgroundThe human health damage caused by laryngeal cancer has attracted worldwide attention. But there is a lack of research on the incidence and mortality trend of laryngeal cancer among Chinese residents from 2005 to 2016.ObjectiveTo describe laryngeal cancer incidence and mortality trends in China from 2005 to 2016 by analyzing the incidence and death data of laryngeal cancer collected from Chinese Cancer Registry Annual Report, providing a reference for scientific prevention and control of laryngeal cancer in China.MethodsData about laryngeal cancer incidence and death in China during 2005—2016 were collected and input into Excel spreadsheets, then the annual standardized incidence, standardized mortality, age-specific incidence and age-specific mortality were calculated. Age-standardized rates were calculated by dividing the number of deaths caused by laryngeal cancer by the fifth national population census (2000) and multiplying by 1 000. Joinpoint Regression Program was adopted to calculate annual percentage change (APC) and average annual percentage change (AAPC) to analyze the temporal trends of annual laryngeal cancer incidence and mortality rates.ResultsFrom 2005 to 2016, the standardized incidence rate of laryngeal cancer in Chinese residents showed a decreasing trend (AAPC=-2.25%, P<0.05) . The overall standardized incidence rate of laryngeal cancer in urban areas was higher than that in rural areas. Males had a significantly higher standardized incidence rate of laryngeal cancer than did females. The incidence of laryngeal cancer increased with age in those aged over 40 years, showing a significant upward trend. And the annual incidence peaks were concentrated in the 70-75-year-old age group. From 2005 to 2014, the overall standardized mortality rate of laryngeal cancer showed a decreasing trend (APC=-1.67%, P<0.05) , although it increased in 2014—2016, the increase was insignificant (P>0.05) . The overall standardized mortality rate in urban areas was higher than that in rural areas. Males had a significantly higher standardized mortality rate than did females. The mortality rate increased gradually with age in those over 40 years old.ConclusionBy and large, the standardized incidence and mortality rates of laryngeal cancer in China showed a downward trend from 2005 to 2016, but showed sex- and age-specific and urban-rural differences. Therefore, targeted measures should be actively taken to develop prevention and treatment strategies to reduce the harm of laryngeal cancer.

Keywords

• |laryngeal neoplasms|incidence|mortality|joinpoint regression analysi