THROMBOPHILIA MARKERS AT WOMEN PATIENTS WITH HISTORY OF FETO-MATERNAL DISEASE AND THROMBOPHILIA

Abstract

The level of molecular markers of a thrombophilia (TAT, D-dimer) and platelet aggregate formation activity allows to estimate risk of obstetric complications at patients with the complicated pregnancy in the anamnesis and a thrombophilia. We observed 63 pregnant women (pregnancy term from 6 to 13 weeks) and 86 women planning pregnancy from which at 54 there was a preeclampsia in the anamnesis at 43 - a premature detachment of placenta, at 52 - antenatal fetal death. 53.0% patients with the complicated pregnancy in the anamnesis had high D-dimer; TAT - 55.0%; aggregation activity of platelets - 59.7%. High level of molecular markers of a thrombophilia are the indication to application the antithrombotic therapy and allow to control efficiency of this therapy

Keywords

• acquired and genetic thrombophilia
• pre-eclampsia
• antiphospholipid syndrome