Molecules (Jan 2010)

A New Flavone C-Glycoside from Clematis rehderiana

  • Zhi-Zhi Du,
  • Xian-Wen Yang,
  • Hao Han,
  • Xiang-Hai Cai,
  • Xiao-Dong Luo

DOI
https://doi.org/10.3390/molecules15020672
Journal volume & issue
Vol. 15, no. 2
pp. 672 – 679

Abstract

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A new flavone C-glycoside, isovitexin 6″-O-E-p-coumarate (1) and two known flavonoid glycosides—quercetin 3-O-β-D-glucuronopyranoside (2) and isoorientin (3)—were isolated from an ethanol extract of aerial parts of Clematis rehderiana. Their structures were determined by spectroscopic methods. The antioxidant effects of the two flavone C-glycosides were evaluated by both the MTT and DPPH assays. Compound 1 showed potent activities against H2O2-induced impairment in PC12 cells within the concentration range tested, whereas compound 3 scavenged DPPH radical strongly, with an IC50 value of 13.5 μM.

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