Nature Communications (Jun 2016)

Notch-independent RBPJ controls angiogenesis in the adult heart

  • Ramón Díaz-Trelles,
  • Maria Cecilia Scimia,
  • Paul Bushway,
  • Danh Tran,
  • Anna Monosov,
  • Edward Monosov,
  • Kirk Peterson,
  • Stacey Rentschler,
  • Pedro Cabrales,
  • Pilar Ruiz-Lozano,
  • Mark Mercola

DOI
https://doi.org/10.1038/ncomms12088
Journal volume & issue
Vol. 7, no. 1
pp. 1 – 10

Abstract

Read online

Heart function after injury improves upon formation of new blood vessels. Here, the authors show that ablating a transcription factor RBPJ in the murine heart increases vascularization and maintains cardiac function after injury by increasing responsiveness to hypoxia, suggesting a new approach to treat heart injury.