Deviant cortical sulcation related to schizophrenia and cognitive deficits in the second trimester

Abstract

Aberrant cortical development, inferred from cortical folding, is linked to the risk of schizophrenia. Cortical folds develop in a time-locked fashion during fetal growth. We leveraged this temporal specificity of sulcation to investigate the timing of the prenatal insult linked to schizophrenia and the cognitive impairment seen in this illness.

Keywords

• sulcation
• gyrification
• schizophrenia
• neurodevelopment
• neurocognition