CHIMIA (Jun 2014)
An Improved Process for the Preparation of an ?,?-Difluorosulfonylisoxazoline Herbicide
- Chantal Belie,
- Andrew Plant,
- Nick Mulholland,
- Matthew McLachlan,
- Derek McCormack,
- Adrian Longstaff,
- Tony Kozakiewicz,
- Andy Knee,
- Katharine Ingram,
- Myriem El Qacemi,
- Martin Diggelmann,
- Jonathan Dallimore,
- Anne Dalençon,
- Eric Clarke,
- Jutta Boehmer,
- John Williams
Affiliations
- Chantal Belie
- Syngenta Crop Protection, Jealott's Hill International Research Centre, Bracknell, Berkshire RG42 6EY, UK
- Andrew Plant
- Syngenta Crop Protection AG, CH-4002 Basel, Switzerland
- Nick Mulholland
- Syngenta Crop Protection, Jealott's Hill International Research Centre, Bracknell, Berkshire RG42 6EY, UK
- Matthew McLachlan
- Syngenta Crop Protection, Jealott's Hill International Research Centre, Bracknell, Berkshire RG42 6EY, UK
- Derek McCormack
- Syngenta Crop Protection, Jealott's Hill International Research Centre, Bracknell, Berkshire RG42 6EY, UK
- Adrian Longstaff
- Syngenta Crop Protection, Jealott's Hill International Research Centre, Bracknell, Berkshire RG42 6EY, UK
- Tony Kozakiewicz
- Syngenta Crop Protection, Jealott's Hill International Research Centre, Bracknell, Berkshire RG42 6EY, UK
- Andy Knee
- Syngenta Crop Protection, Jealott's Hill International Research Centre, Bracknell, Berkshire RG42 6EY, UK
- Katharine Ingram
- Syngenta Crop Protection, Jealott's Hill International Research Centre, Bracknell, Berkshire RG42 6EY, UK
- Myriem El Qacemi
- Syngenta Crop Protection Münchwilen AG, Schaffhauserstrasse, CH-4332 Stein, Switzerland. [email protected]
- Martin Diggelmann
- Syngenta Crop Protection AG, CH-4002 Basel, Switzerland
- Jonathan Dallimore
- Syngenta Crop Protection, Jealott's Hill International Research Centre, Bracknell, Berkshire RG42 6EY, UK
- Anne Dalençon
- Syngenta Crop Protection, Jealott's Hill International Research Centre, Bracknell, Berkshire RG42 6EY, UK
- Eric Clarke
- Syngenta Crop Protection, Jealott's Hill International Research Centre, Bracknell, Berkshire RG42 6EY, UK
- Jutta Boehmer
- Syngenta Crop Protection, Jealott's Hill International Research Centre, Bracknell, Berkshire RG42 6EY, UK
- John Williams
- Syngenta Crop Protection, Jealott's Hill International Research Centre, Bracknell, Berkshire RG42 6EY, UK
- DOI
- https://doi.org/10.2533/chimia.2014.442
- Journal volume & issue
-
Vol. 68,
no. 6
Abstract
An efficient synthesis of a difluorosulfone-containing herbicide has been achieved by selective reductive silylation of a symmetrical bis(trifluoromethyl)-1,2,3-triazole. Subsequently, a fluoride-induced reaction led to a difluoromethyl anion equivalent, which was reacted with a sulfur electrophile leading ultimately to the key difluorosulfide moiety.
Keywords
