Highly selective single and multiple deuteration of unactivated C(sp3)-H bonds

Nian Li; Jinhang Li; Mingzhe Qin; Jiajun Li; Jie Han; Chengjian Zhu; Weipeng Li; Jin Xie

doi:10.1038/s41467-022-31956-3

Nature Communications (Jul 2022)

Highly selective single and multiple deuteration of unactivated C(sp3)-H bonds

Nian Li,
Jinhang Li,
Mingzhe Qin,
Jiajun Li,
Jie Han,
Chengjian Zhu,
Weipeng Li,
Jin Xie

Affiliations

Nian Li: State Key Laboratory of Coordination Chemistry, Jiangsu Key Laboratory of Advanced Organic Materials, Chemistry and Biomedicine Innovation Center (ChemBIC), School of Chemistry and Chemical Engineering, Nanjing University
Jinhang Li: State Key Laboratory of Coordination Chemistry, Jiangsu Key Laboratory of Advanced Organic Materials, Chemistry and Biomedicine Innovation Center (ChemBIC), School of Chemistry and Chemical Engineering, Nanjing University
Mingzhe Qin: State Key Laboratory of Coordination Chemistry, Jiangsu Key Laboratory of Advanced Organic Materials, Chemistry and Biomedicine Innovation Center (ChemBIC), School of Chemistry and Chemical Engineering, Nanjing University
Jiajun Li: State Key Laboratory of Coordination Chemistry, Jiangsu Key Laboratory of Advanced Organic Materials, Chemistry and Biomedicine Innovation Center (ChemBIC), School of Chemistry and Chemical Engineering, Nanjing University
Jie Han: State Key Laboratory of Coordination Chemistry, Jiangsu Key Laboratory of Advanced Organic Materials, Chemistry and Biomedicine Innovation Center (ChemBIC), School of Chemistry and Chemical Engineering, Nanjing University
Chengjian Zhu: State Key Laboratory of Coordination Chemistry, Jiangsu Key Laboratory of Advanced Organic Materials, Chemistry and Biomedicine Innovation Center (ChemBIC), School of Chemistry and Chemical Engineering, Nanjing University
Weipeng Li: State Key Laboratory of Coordination Chemistry, Jiangsu Key Laboratory of Advanced Organic Materials, Chemistry and Biomedicine Innovation Center (ChemBIC), School of Chemistry and Chemical Engineering, Nanjing University
Jin Xie: State Key Laboratory of Coordination Chemistry, Jiangsu Key Laboratory of Advanced Organic Materials, Chemistry and Biomedicine Innovation Center (ChemBIC), School of Chemistry and Chemical Engineering, Nanjing University

DOI: https://doi.org/10.1038/s41467-022-31956-3
Journal volume & issue: Vol. 13, no. 1
pp. 1 – 8

Abstract

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Deuteration of unactivated C(sp3)̵̵̵̵̵̵̵̵–H bonds is a simple route to deuterated compounds, of use in pharmaceutical chemistry, material science, and synthetic chemistry. Here, the authors describe a hydrogen/deuterium (H/D) exchange of remote unactivated C(sp3)̵̵̵̵̵̵̵̵–H bonds via photocatalysis, proceeding through hydrogen atom transfer.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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