Therapeutic Advances in Urology (Aug 2016)

Optimal treatment of tuberous sclerosis complex associated renal angiomyolipomata: a systematic review

  • John J. Bissler,
  • John C. Kingswood

DOI
https://doi.org/10.1177/1756287216641353
Journal volume & issue
Vol. 8

Abstract

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Renal angiomyolipomata associated with tuberous sclerosis complex are often bilateral, multiple and progressive. They cause significant morbidity and mortality in older children and adults. Surveillance and pre-emptive treatment reduce this risk. Recent research suggests treatment with mammalian target of rapamycin inhibitors is better at preventing bleeding, recurrence, and preserving renal function than percutaneous embolization.