AIMS Molecular Science (Jan 2021)

A mini review on the associations of matrix metalloproteinases (MMPs) -1, -8, -13 with periodontal disease

  • Fazle Khuda,
  • Nur Najmi Mohamad Anuar ,
  • Badiah Baharin,
  • Nurrul Shaqinah Nasruddin

DOI
https://doi.org/10.3934/molsci.2021002
Journal volume & issue
Vol. 8, no. 1
pp. 13 – 31

Abstract

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Matrix metalloproteinases (MMPs) are one of the most important endopeptidases in periodontal disease that generally degrade extracellular matrix (ECM) components of periodontal supporting tissues, leading to tooth loss. Among the MMP family, MMP-1, -8 and -13, which are also known as the collagenase group, play a vital role in the degradation of ECM collagen and non-collagen substances. Elevated levels of MMP -1, -8 and -13 are markedly significant within tissue, gingival crevicular fluid (GCF), and saliva of patients with periodontitis, which help to explain the progression pattern of the disease. This review provides an overview of MMP -1, -8, and -13 on their structures, functions and their critical role in periodontitis.

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