A low‐intensity 10‐min resistance exercise program that ameliorated hepatic fibrosis indices and altered G‐CSF/IP‐10/PDGF‐BB in a patient with nonalcoholic fatty liver disease: A case report
Ryuki Hashida,
Dan Nakano,
Hiroo Matsuse,
Sachiyo Yoshio,
Tsubasa Tsutsumi,
Machiko Kawaguchi,
Shunji Koya,
Keisuke Hirota,
Hiroshi Tajima,
Yoshio Sumida,
Tatsuya Kanto,
Takumi Kawaguchi,
Koji Hiraoka
Affiliations
Ryuki Hashida
Department of Orthopedics, School of Medicine Kurume University Kurume Japan
Dan Nakano
Division of Gastroenterology, Department of Medicine Kurume University School of Medicine Kurume Japan
Hiroo Matsuse
Department of Orthopedics, School of Medicine Kurume University Kurume Japan
Sachiyo Yoshio
Department of Liver Disease, The Research Center for Hepatitis and Immunology National Center for Global Health and Medicine Ichikawa Japan
Tsubasa Tsutsumi
Division of Gastroenterology, Department of Medicine Kurume University School of Medicine Kurume Japan
Machiko Kawaguchi
Division of Gastroenterology, Department of Medicine Kurume University School of Medicine Kurume Japan
Shunji Koya
Division of Rehabilitation Kurume University Hospital Kurume Japan
Keisuke Hirota
Division of Rehabilitation Kurume University Hospital Kurume Japan
Hiroshi Tajima
Department of Orthopedics, School of Medicine Kurume University Kurume Japan
Yoshio Sumida
Division of Hepatology and Pancreatology, Department of Internal Medicine Aichi Medical University Nagakute Japan
Tatsuya Kanto
Department of Liver Disease, The Research Center for Hepatitis and Immunology National Center for Global Health and Medicine Ichikawa Japan
Takumi Kawaguchi
Division of Gastroenterology, Department of Medicine Kurume University School of Medicine Kurume Japan
Koji Hiraoka
Department of Orthopedics, School of Medicine Kurume University Kurume Japan
Abstract We developed a low‐intensity 10‐min resistance exercise program for nonalcoholic fatty liver disease (NAFLD). We report a case of NAFLD with elevated hepatic fibrosis indices, which were improved by a 60‐week daily exercise program. A 71‐year‐old female patient with NAFLD whose hepatic fibrosis stage corresponded to F2 was referred to our hospital. She performed the exercise once a day with no changes in other lifestyle habits and medications. The homeostasis model assessment‐insulin resistance value and NAFLD‐liver fat score, the Hepamet fibrosis score, and the enhanced liver fibrosis score decreased. The FIB‐4 index and serum levels of Mac‐2 binding protein glycosylation isomer decreased to the reference values. We investigated the changes in chemokines/cytokines. The serum granulocyte‐colony stimulating factor level was increased, and serum interferon‐gamma‐induced protein‐10 and platelet‐derived growth factor‐BB levels were decreased. Our program may be beneficial for improving hepatic fibrosis in patients with NAFLD.
