Specific length and structure rather than high thermodynamic stability enable regulatory mRNA stem-loops to pause translation

Chen Bao; Mingyi Zhu; Inna Nykonchuk; Hironao Wakabayashi; David H. Mathews; Dmitri N. Ermolenko

doi:10.1038/s41467-022-28600-5

Nature Communications (Feb 2022)

Specific length and structure rather than high thermodynamic stability enable regulatory mRNA stem-loops to pause translation

Chen Bao,
Mingyi Zhu,
Inna Nykonchuk,
Hironao Wakabayashi,
David H. Mathews,
Dmitri N. Ermolenko

Affiliations

Chen Bao: Department of Biochemistry & Biophysics at School of Medicine and Dentistry and Center for RNA Biology, University of Rochester
Mingyi Zhu: Department of Biochemistry & Biophysics at School of Medicine and Dentistry and Center for RNA Biology, University of Rochester
Inna Nykonchuk: Department of Biochemistry & Biophysics at School of Medicine and Dentistry and Center for RNA Biology, University of Rochester
Hironao Wakabayashi: Department of Biochemistry & Biophysics at School of Medicine and Dentistry and Center for RNA Biology, University of Rochester
David H. Mathews: Department of Biochemistry & Biophysics at School of Medicine and Dentistry and Center for RNA Biology, University of Rochester
Dmitri N. Ermolenko: Department of Biochemistry & Biophysics at School of Medicine and Dentistry and Center for RNA Biology, University of Rochester

DOI: https://doi.org/10.1038/s41467-022-28600-5
Journal volume & issue: Vol. 13, no. 1
pp. 1 – 14

Abstract

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This study shows that rather than high thermodynamic stability, specific length and structure enable regulatory mRNA stem-loops to pause translation. These findings aid identification of new regulatory mRNA stem-loops.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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