Screening Privileged Alkyl Guanidinium Motifs under Host-Mimicking Conditions Reveals a Novel Antibiotic with an Unconventional Mode of Action

• Dominik Schum,
• Franziska A. V. Elsen,
• Stuart Ruddell,
• Kenji Schorpp,
• Howard Junca,
• Mathias Müsken,
• Shu-Yu Chen,
• Michaela K. Fiedler,
• Thomas Pickl,
• Dietmar H. Pieper,
• Kamyar Hadian,
• Martin Zacharias,
• Stephan A. Sieber

Affiliations

Dominik Schum

TUM School of Natural Sciences, Department of Bioscience, Chair of Organic Chemistry II, Center for Functional Protein Assemblies (CPA), Technical University of Munich (TUM), Garching, Germany

Franziska A. V. Elsen

TUM School of Natural Sciences, Department of Bioscience, Chair of Organic Chemistry II, Center for Functional Protein Assemblies (CPA), Technical University of Munich (TUM), Garching, Germany

Stuart Ruddell

TUM School of Natural Sciences, Department of Bioscience, Chair of Organic Chemistry II, Center for Functional Protein Assemblies (CPA), Technical University of Munich (TUM), Garching, Germany

Kenji Schorpp

Helmholtz Zentrum München, Research Unit Signaling and Translation, Munich, Germany

Howard Junca

Helmholtz Centre for Infection Research, Microbial Interactions and Processes, Braunschweig, Germany

Mathias Müsken

Helmholtz Centre for Infection Research, Central Facility for Microscopy, Braunschweig, Germany

Shu-Yu Chen

TUM School of Natural Sciences, Department of Bioscience, Theoretical Biophysics (T38), Center for Functional Protein Assemblies (CPA), Technical University of Munich (TUM), Garching, Germany

Michaela K. Fiedler

TUM School of Natural Sciences, Department of Bioscience, Chair of Organic Chemistry II, Center for Functional Protein Assemblies (CPA), Technical University of Munich (TUM), Garching, Germany

Thomas Pickl

TUM School of Natural Sciences, Department of Chemistry, Catalysis Research Center (CRC), Technical University of Munich (TUM), Garching, Germany

Dietmar H. Pieper

Helmholtz Centre for Infection Research, Microbial Interactions and Processes, Braunschweig, Germany

Kamyar Hadian

Helmholtz Zentrum München, Research Unit Signaling and Translation, Munich, Germany

Martin Zacharias

TUM School of Natural Sciences, Department of Bioscience, Theoretical Biophysics (T38), Center for Functional Protein Assemblies (CPA), Technical University of Munich (TUM), Garching, Germany

Stephan A. Sieber

TUM School of Natural Sciences, Department of Bioscience, Chair of Organic Chemistry II, Center for Functional Protein Assemblies (CPA), Technical University of Munich (TUM), Garching, Germany