Cryo-EM, Protein Engineering, and Simulation Enable the Development of Peptide Therapeutics against Acute Myeloid Leukemia

• Kaiming Zhang,
• Naoki Horikoshi,
• Shanshan Li,
• Alexander S. Powers,
• Mikhail A. Hameedi,
• Grigore D. Pintilie,
• Hee-Don Chae,
• Yousuf A. Khan,
• Carl-Mikael Suomivuori,
• Ron O. Dror,
• Kathleen M. Sakamoto,
• Wah Chiu,
• Soichi Wakatsuki

Affiliations

Kaiming Zhang

MOE Key Laboratory for Cellular Dynamics and Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, China

Naoki Horikoshi

Life Science Center for Survival Dynamics, University of Tsukuba, Tsukuba, Ibaraki, Japan

Shanshan Li

MOE Key Laboratory for Cellular Dynamics and Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, China

Alexander S. Powers

Department of Chemistry, Stanford University, Stanford, California, United States

Mikhail A. Hameedi

Department of Structural Biology, Stanford University, Stanford, California, United States

Grigore D. Pintilie

Department of Bioengineering, Stanford University, Stanford, California, United States

Hee-Don Chae

Department of Pediatrics, Stanford University School of Medicine, Stanford, California, United States

Yousuf A. Khan

Department of Computer Science, Stanford University, Stanford, California, United States

Carl-Mikael Suomivuori

Department of Computer Science, Stanford University, Stanford, California, United States

Ron O. Dror

Department of Computer Science, Stanford University, Stanford, California, United States

Kathleen M. Sakamoto

Department of Pediatrics, Stanford University School of Medicine, Stanford, California, United States

Wah Chiu

Department of Bioengineering, Stanford University, Stanford, California, United States

Soichi Wakatsuki

Department of Structural Biology, Stanford University, Stanford, California, United States