Evaluation of Dyslipidaemia and Echocardiographic Markers of Myocardial Contractility in Smokers with Ischaemic Heart Disease

Abstract

Introduction: Cigarette smoking is responsible for dyslipidaemia and haemodynamic disturbances. Aim: The present study was conducted to evaluate the parameters of dyslipidaemia and left ventricular ejection fraction in smokers with Ischemic Heart Disease (IHD). Materials and Methods: Total number of study subjects included 327 males, which included 127 healthy subjects and 200 subjects admitted as IHD patients under the inclusion criteria meant for categorizing chronic smokers. They were subsequently divided into smoker and non-smoker groups and evaluated for lipid profile and 2D echocardiography. Results: The parameters of lipid profile revealed significant difference (p<0.001) in all lipid parameters except HDL among non-smokers vs smokers in both patient and control groups. The echocardiography analysis suggested significantly (<0.001) reduced ejection fraction in patients with smoking habit compared to without smoking habit. Conclusion: Chronic smokers with history of ≥15 pack years should undergo screening for IHD by timely evaluation of ejection fraction along with estimation of lipid profile.

Keywords

• ejection fraction
• lipid profile
• nicotine