Nature Communications (Jun 2017)

CIB2 interacts with TMC1 and TMC2 and is essential for mechanotransduction in auditory hair cells

  • Arnaud P. J. Giese,
  • Yi-Quan Tang,
  • Ghanshyam P. Sinha,
  • Michael R. Bowl,
  • Adam C. Goldring,
  • Andrew Parker,
  • Mary J. Freeman,
  • Steve D. M. Brown,
  • Saima Riazuddin,
  • Robert Fettiplace,
  • William R. Schafer,
  • Gregory I. Frolenkov,
  • Zubair M. Ahmed

DOI
https://doi.org/10.1038/s41467-017-00061-1
Journal volume & issue
Vol. 8, no. 1
pp. 1 – 13

Abstract

Read online

Inner ear hair cells detect sound through deflection of stereocilia that harbor mechanically-gated channels. Here the authors show that protein responsible for Usher syndrome, CIB2, interacts with these channels and is essential for their function and hearing in mice.