Nature Communications (Nov 2022)

DNA barcoding reveals ongoing immunoediting of clonal cancer populations during metastatic progression and immunotherapy response

  • Louise A. Baldwin,
  • Nenad Bartonicek,
  • Jessica Yang,
  • Sunny Z. Wu,
  • Niantao Deng,
  • Daniel L. Roden,
  • Chia-Ling Chan,
  • Ghamdan Al-Eryani,
  • Damien J. Zanker,
  • Belinda S. Parker,
  • Alexander Swarbrick,
  • Simon Junankar

DOI
https://doi.org/10.1038/s41467-022-34041-x
Journal volume & issue
Vol. 13, no. 1
pp. 1 – 18

Abstract

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Understanding the molecular mechanisms of cancer immunoediting could provide insight into resistance to immunotherapy. Here, DNA barcoding provides evidence of ongoing immunoediting during metastasis and treatment with anti-PD1 and anti-CTLA4, and identifies cancer cell clones with unique immune evasive phenotypes.