Journal of Inflammation Research (Feb 2024)
The Hippo-YAP Signaling Pathway in Osteoarthritis and Rheumatoid Arthritis
Abstract
Min Li,1 Fang-Jie Zhang,2,3 Rui-Jun Bai1 1Department of Orthopaedics, Wuxi Ninth People’s Hospital, Soochow University, Wuxi, Jiangsu, 214000, People’s Republic of China; 2National Clinical Research Center for Geriatric Disorders (Xiangya Hospital), Changsha, Hunan, 410008, People’s Republic of China; 3Department of Emergency Medicine, Xiangya Hospital, Central South University, Changsha, Hunan, 410008, People’s Republic of ChinaCorrespondence: Rui-Jun Bai, Department of Orthopaedics, Wuxi Ninth People’s Hospital, Soochow University, Wuxi, People’s Republic of China, Tel +86-15155580215, Fax +86-510-85867999, Email [email protected] Fang-Jie Zhang, National Clinical Research Center for Geriatric Disorders (Xiangya Hospital), Changsha, Hunan, 410008, People’s Republic of China, Tel +86-15116256248, Fax +86-871-84327332, Email [email protected]: Arthritis is the most prevalent joint disease and is characterized by articular cartilage degradation, synovial inflammation, and changes in periarticular and subchondral bone. Recent studies have reported that Yes-associated protein (YAP) and the transcriptional coactivator with PDZ-binding motif (TAZ) have significant effects on the proliferation, migration, and survival of chondrocytes and fibroblast-like synovial cells (FLSs). YAP/TAZ signaling pathway, as well as the related Hippo–YAP signaling pathway, are responsible for the condition of cells and articular cartilage in joints. They are tightly regulated to maintain metabolism in chondrocytes and FLSs because abnormal expression may result in cartilage damage. However, the roles and mechanisms of the Hippo–YAP pathway in arthritis remain largely unknown. This review summarizes the roles and key functions of YAP/TAZ and the Hippo–YAP signaling pathway in FLSs and chondrocytes for the induction of proliferation, migration, survival, and differentiation in rheumatoid arthritis (RA) and osteoarthritis (OA) research. We also discuss the therapeutic strategies involving YAP/TAZ and the related Hippo-YAP signaling pathway involved in OA.Keywords: YAP/TAZ, osteoarthritis, rheumatoid arthritis, chondrocytes, therapy
