Nature Communications (Dec 2022)

Gut microbiome-wide association study of depressive symptoms

  • Djawad Radjabzadeh,
  • Jos A. Bosch,
  • André G. Uitterlinden,
  • Aeilko H. Zwinderman,
  • M. Arfan Ikram,
  • Joyce B. J. van Meurs,
  • Annemarie I. Luik,
  • Max Nieuwdorp,
  • Anja Lok,
  • Cornelia M. van Duijn,
  • Robert Kraaij,
  • Najaf Amin

DOI
https://doi.org/10.1038/s41467-022-34502-3
Journal volume & issue
Vol. 13, no. 1
pp. 1 – 10

Abstract

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Here, the authors analyze the relation of fecal microbiota diversity and composition with depressive symptoms in 1,054 participants from the Rotterdam Study cohort and in 1,539 subjects of the Amsterdam HELIUS cohort, finding associations with bacteria known to be involved in the synthesis of key neurotransmitters for depression.