CPEB2 m6A methylation regulates blood–tumor barrier permeability by regulating splicing factor SRSF5 stability

Mengyang Zhang; Chunqing Yang; Xuelei Ruan; Xiaobai Liu; Di Wang; Libo Liu; Lianqi Shao; Ping Wang; Weiwei Dong; Yixue Xue

doi:10.1038/s42003-022-03878-9

Communications Biology (Sep 2022)

CPEB2 m6A methylation regulates blood–tumor barrier permeability by regulating splicing factor SRSF5 stability

Mengyang Zhang,
Chunqing Yang,
Xuelei Ruan,
Xiaobai Liu,
Di Wang,
Libo Liu,
Lianqi Shao,
Ping Wang,
Weiwei Dong,
Yixue Xue

Affiliations

Mengyang Zhang: Department of Neurobiology, School of Life Sciences, China Medical University
Chunqing Yang: Department of Neurosurgery, Shengjing Hospital of China Medical University
Xuelei Ruan: Department of Neurobiology, School of Life Sciences, China Medical University
Xiaobai Liu: Department of Neurosurgery, Shengjing Hospital of China Medical University
Di Wang: Department of Neurosurgery, Shengjing Hospital of China Medical University
Libo Liu: Department of Neurobiology, School of Life Sciences, China Medical University
Lianqi Shao: Department of Neurobiology, School of Life Sciences, China Medical University
Ping Wang: Department of Neurobiology, School of Life Sciences, China Medical University
Weiwei Dong: Department of Neurosurgery, Shengjing Hospital of China Medical University
Yixue Xue: Department of Neurobiology, School of Life Sciences, China Medical University

DOI: https://doi.org/10.1038/s42003-022-03878-9
Journal volume & issue: Vol. 5, no. 1
pp. 1 – 14

Abstract

Read online

The methyl transferase METTL3 is up-regulated in brain tumors leading to the methylation of CPEB2 mRNA, which in turn stabilizes the splicing factor SRSF5 mRNA, leading to the incorporation of exon 7 in ETS-1 in models of the Blood–Tumor Barrier.

Published in Communications Biology

ISSN: 2399-3642 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science: Biology (General)
Website: https://www.nature.com/commsbio/

About the journal