A realization form of the Mie resonance with adjustable characteristics based on a water-based metamaterial is proposed. A novel local electromagnetic field coupling mechanism based on a water-based metamaterial is established, which is used for transmission enhancement through the sub-wavelength aperture for the first time. The water-based metamaterial particle for transmission enhancement at a specific frequency is designed. By designing the microfluidic control system to control the water filling (i.e., height) of the metamaterial particle, the adjustable transmission enhancement characteristics are realized. The influence of bilateral symmetry and flexible deformation of the metamaterial particle on the transmission characteristics is analyzed. The influence of the design parameters on the enhanced transmission characteristics is discussed.