Nature Communications (Aug 2018)

Interferon priming is essential for human CD34+ cell-derived plasmacytoid dendritic cell maturation and function

  • A. Laustsen,
  • R. O. Bak,
  • C. Krapp,
  • L. Kjær,
  • J. H. Egedahl,
  • C. C. Petersen,
  • S. Pillai,
  • H. Q. Tang,
  • N. Uldbjerg,
  • M. Porteus,
  • N. R. Roan,
  • M. Nyegaard,
  • P. W. Denton,
  • M. R. Jakobsen

DOI
https://doi.org/10.1038/s41467-018-05816-y
Journal volume & issue
Vol. 9, no. 1
pp. 1 – 14

Abstract

Read online

Plasmacytoid dendritic cells (pDC) are an important regulator of immune responses. Here the authors show that pDC precursors, similar to peripheral blood-derived pDCs, can be differentiated from human CD34+ hematopoietic stem and progenitor cells, with type I/II IFN priming being required for their functional maturation and differentiation.