Distribution of photosensitizer based on inditricarbocyanine dye in the animal tissues in vivo

Abstract

The photosensitizer based on indotricarbocyanine dye distribution in the laboratory animals tissues in vivo have been studied by diffusion fluorescent tomography with FMT 4000 (Perkin Elmer, USA). Nu/Nu mice with tumors fluorescent 3D images were recorded at different time after intravenous introduction of the indotricarbocyanine dye. The indotricarbocyanine dye pharmacokinetics was determined at concentration of 1 mg/kg. It was established that 40-60 minutes after intravenous introduction dye quasistationary value of concentration in the tissues reaches.

Keywords

• polymethine dyes
• photosensitizers
• pharmacokinetics
• diffusion fluorescence tomography