Prospective cohort studies underscore the association of abnormal glycemic measures with all-cause and cause-specific mortalities
Juzhong Ke,
Xiaonan Ruan,
Wenbin Liu,
Xiaolin Liu,
Kang Wu,
Hua Qiu,
Xiaonan Wang,
Yibo Ding,
Xiaojie Tan,
Zhitao Li,
Guangwen Cao
Affiliations
Juzhong Ke
Center for Disease Control and Prevention of Pudong New Area, Pudong Institute of Preventive Medicine, Fudan University, Shanghai, P.R. China
Xiaonan Ruan
Center for Disease Control and Prevention of Pudong New Area, Pudong Institute of Preventive Medicine, Fudan University, Shanghai, P.R. China
Wenbin Liu
Department of Epidemiology, Second Military Medical University, Shanghai, P.R. China; Shanghai Key Laboratory of Medical Bioprotection, Shanghai, P.R. China; Key Laboratory of Biological Defense, Ministry of Education, Shanghai, P.R. China
Xiaolin Liu
Center for Disease Control and Prevention of Pudong New Area, Pudong Institute of Preventive Medicine, Fudan University, Shanghai, P.R. China
Kang Wu
Center for Disease Control and Prevention of Pudong New Area, Pudong Institute of Preventive Medicine, Fudan University, Shanghai, P.R. China
Hua Qiu
Center for Disease Control and Prevention of Pudong New Area, Pudong Institute of Preventive Medicine, Fudan University, Shanghai, P.R. China
Xiaonan Wang
Center for Disease Control and Prevention of Pudong New Area, Pudong Institute of Preventive Medicine, Fudan University, Shanghai, P.R. China
Yibo Ding
Department of Epidemiology, Second Military Medical University, Shanghai, P.R. China; Shanghai Key Laboratory of Medical Bioprotection, Shanghai, P.R. China; Key Laboratory of Biological Defense, Ministry of Education, Shanghai, P.R. China
Xiaojie Tan
Department of Epidemiology, Second Military Medical University, Shanghai, P.R. China; Shanghai Key Laboratory of Medical Bioprotection, Shanghai, P.R. China; Key Laboratory of Biological Defense, Ministry of Education, Shanghai, P.R. China
Zhitao Li
Center for Disease Control and Prevention of Pudong New Area, Pudong Institute of Preventive Medicine, Fudan University, Shanghai, P.R. China
Guangwen Cao
Department of Epidemiology, Second Military Medical University, Shanghai, P.R. China; Shanghai Key Laboratory of Medical Bioprotection, Shanghai, P.R. China; Key Laboratory of Biological Defense, Ministry of Education, Shanghai, P.R. China; Corresponding author
Summary: The role of fasting plasma glucose (FPG), glycated hemoglobin (HbA1c), and triglyceride-glucose index (TyG index) in predicting all-cause and cause-specific mortalities remains elusive. This study included 384,420 adults from the Shanghai cohort and the UK Biobank (UKB) cohort. After multivariable adjustment in the Cox models, FPG ≥7.0 mmol/L or HbA1c ≥ 6.5% increased the risk of all-cause mortality, FPG ≥5.6 mmol/L or HbA1c ≥ 6.5% increased CVD-related mortality, and higher or lower TyG index increased all-cause and CVD-related mortalities in the Shanghai cohort; FPG ≥5.6 mmol/L, HbA1c ≥ 5.7%, TyG index <8.31 or ≥9.08 increased the risks of all-cause, CVD-related, and cancer-related mortalities in the UKB cohort. FPG or HbA1c increased the discrimination of the conventional risk model in predicting all-cause and CVD-related mortalities in both cohorts. Thus, increased levels of FPG and HbA1c and U-shaped TyG index increase the risks of all-cause especially CVD-related mortalities.
